PEDIATRIC CHRONIC PANCREATITIS IS ASSOCIATED WITH GENETIC RISK FACTORS AND SUBSTANTIAL DISEASE BURDEN
Identifieur interne : 001C85 ( Main/Exploration ); précédent : 001C84; suivant : 001C86PEDIATRIC CHRONIC PANCREATITIS IS ASSOCIATED WITH GENETIC RISK FACTORS AND SUBSTANTIAL DISEASE BURDEN
Auteurs : Sarah Jane Schwarzenberg [États-Unis] ; Melena Bellin [États-Unis] ; Sohail Z. Husain [États-Unis] ; Monika Ahuja [États-Unis] ; Bradley Barth [États-Unis] ; Heather Davis [États-Unis] ; Peter R. Durie [Canada] ; Douglas S. Fishman [États-Unis] ; Steven D. Freedman [États-Unis] ; Cheryl E. Gariepy [États-Unis] ; Matthew J. Giefer [États-Unis] ; Tanja Gonska [Canada] ; Melvin B. Heyman [États-Unis] ; Ryan Himes [États-Unis] ; Soma Kumar [États-Unis] ; Veronique D. Morinville [Canada] ; Mark E. Lowe [États-Unis] ; Neil E. Nuehring [États-Unis] ; Chee Y. Ooi [Australie] ; John F. Pohl [États-Unis] ; David Troendle [États-Unis] ; Steven L. Werlin [États-Unis] ; Michael Wilschanski [Israël] ; Elizabeth Yen [États-Unis] ; Aliye Uc [États-Unis]Source :
- The Journal of pediatrics [ 0022-3476 ] ; 2014.
Descripteurs français
- KwdFr :
- ADN (génétique), Analyse de mutations d'ADN, Cholangiopancréatographie rétrograde endoscopique, Enfant, Facteurs de risque, Femelle, Humains, Incidence, Mutation, Mâle, Pancréatite chronique (diagnostic), Pancréatite chronique (génétique), Pancréatite chronique (épidémiologie), Protéine CFTR (génétique), Prédisposition génétique à une maladie, Prévalence, États-Unis d'Amérique (épidémiologie), Études transversales.
- MESH :
- diagnostic : Pancréatite chronique.
- génétique : ADN, Pancréatite chronique, Protéine CFTR.
- épidémiologie : Pancréatite chronique, États-Unis d'Amérique.
- Analyse de mutations d'ADN, Cholangiopancréatographie rétrograde endoscopique, Enfant, Facteurs de risque, Femelle, Humains, Incidence, Mutation, Mâle, Prédisposition génétique à une maladie, Prévalence, Études transversales.
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Child, Cholangiopancreatography, Endoscopic Retrograde, Cross-Sectional Studies, Cystic Fibrosis Transmembrane Conductance Regulator (genetics), DNA (genetics), DNA Mutational Analysis, Female, Genetic Predisposition to Disease, Humans, Incidence, Male, Mutation, Pancreatitis, Chronic (diagnosis), Pancreatitis, Chronic (epidemiology), Pancreatitis, Chronic (genetics), Prevalence, Risk Factors, United States (epidemiology).
- MESH :
- chemical , genetics : Cystic Fibrosis Transmembrane Conductance Regulator, DNA.
- geographic , epidemiology : United States.
- diagnosis : Pancreatitis, Chronic.
- epidemiology : Pancreatitis, Chronic.
- genetics : Pancreatitis, Chronic.
- Child, Cholangiopancreatography, Endoscopic Retrograde, Cross-Sectional Studies, DNA Mutational Analysis, Female, Genetic Predisposition to Disease, Humans, Incidence, Male, Mutation, Prevalence, Risk Factors.
Abstract
To determine the clinical presentation, diagnostic variables, risk factors and disease burden in children with chronic pancreatitis.
We performed a cross-sectional study of data from INSPPIRE (
Among 170 subjects in the registry, 76 (45%) had chronic pancreatitis; 57% were female, 80% were Caucasian, median age at diagnosis was 9.9 years. Pancreatitis-predisposing genetic mutations were identified in 51 (67%) and obstructive risk factors in 25 (33%). Toxic/metabolic and autoimmune factors were uncommon. Imaging demonstrated ductal abnormalities and pancreatic atrophy more commonly than calcifications. Fifty-nine (77%) reported abdominal pain within the past year; pain was reported as constant and receiving narcotics in 28%. Children with chronic pancreatitis reported a median of 3 emergency room visits and 2 hospitalizations in the last year. Forty-seven subjects (70%) missed one day of school in the past month due to chronic pancreatitis; 26 (34%) missed 3 or more days. Children reporting constant pain were more likely to miss school (p=0.002), visit emergency room (p=0.01) and experience hospitalizations (p=0.03) compared with children with episodic pain. Thirty-three children (43%) underwent therapeutic ERCP; one or more pancreatic surgeries were performed in 30 (39%).
Chronic pancreatitis occurs at a young age with distinct clinical features. Genetic and obstructive risk factors are common, and disease burden is substantial.
Url:
DOI: 10.1016/j.jpeds.2014.11.019
PubMed: 25556020
PubMed Central: 4380827
Affiliations:
- Australie, Canada, Israël, États-Unis
- Californie, Iowa, Massachusetts, Minnesota, Ohio, Pennsylvanie, Québec, Texas, Utah, Washington (État), Wisconsin
- Montréal
- Université McGill
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Pohl</name><affiliation wicri:level="2"><nlm:aff id="A13">University of Utah, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Troendle, David" sort="Troendle, David" uniqKey="Troendle D" first="David" last="Troendle">David Troendle</name><affiliation wicri:level="2"><nlm:aff id="A4">University of Texas Southwestern Medical School, Dallas, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas Southwestern Medical School, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Werlin, Steven L" sort="Werlin, Steven L" uniqKey="Werlin S" first="Steven L." last="Werlin">Steven L. 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Husain</name><affiliation wicri:level="2"><nlm:aff id="A2">Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children’s Hospital of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ahuja, Monika" sort="Ahuja, Monika" uniqKey="Ahuja M" first="Monika" last="Ahuja">Monika Ahuja</name><affiliation wicri:level="2"><nlm:aff id="A3">University of Iowa Carver College of Medicine, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Iowa Carver College of Medicine, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Barth, Bradley" sort="Barth, Bradley" uniqKey="Barth B" first="Bradley" last="Barth">Bradley Barth</name><affiliation wicri:level="2"><nlm:aff id="A4">University of Texas Southwestern Medical School, Dallas, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas Southwestern Medical School, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Davis, Heather" sort="Davis, Heather" uniqKey="Davis H" first="Heather" last="Davis">Heather Davis</name><affiliation wicri:level="2"><nlm:aff id="A3">University of Iowa Carver College of Medicine, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Iowa Carver College of Medicine, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Durie, Peter R" sort="Durie, Peter R" uniqKey="Durie P" first="Peter R." last="Durie">Peter R. Durie</name><affiliation wicri:level="1"><nlm:aff id="A5">Hospital for Sick Children, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Hospital for Sick Children, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Fishman, Douglas S" sort="Fishman, Douglas S" uniqKey="Fishman D" first="Douglas S." last="Fishman">Douglas S. Fishman</name><affiliation wicri:level="2"><nlm:aff id="A6">Baylor College of Medicine, Houston, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor College of Medicine, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Freedman, Steven D" sort="Freedman, Steven D" uniqKey="Freedman S" first="Steven D." last="Freedman">Steven D. Freedman</name><affiliation wicri:level="2"><nlm:aff id="A7">Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gariepy, Cheryl E" sort="Gariepy, Cheryl E" uniqKey="Gariepy C" first="Cheryl E." last="Gariepy">Cheryl E. Gariepy</name><affiliation wicri:level="2"><nlm:aff id="A8">Nationwide Children’s Hospital, Columbus, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Nationwide Children’s Hospital, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Giefer, Matthew J" sort="Giefer, Matthew J" uniqKey="Giefer M" first="Matthew J." last="Giefer">Matthew J. Giefer</name><affiliation wicri:level="2"><nlm:aff id="A9">Seattle Children’s Hospital, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Seattle Children’s Hospital, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Gonska, Tanja" sort="Gonska, Tanja" uniqKey="Gonska T" first="Tanja" last="Gonska">Tanja Gonska</name><affiliation wicri:level="1"><nlm:aff id="A5">Hospital for Sick Children, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Hospital for Sick Children, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Heyman, Melvin B" sort="Heyman, Melvin B" uniqKey="Heyman M" first="Melvin B." last="Heyman">Melvin B. Heyman</name><affiliation wicri:level="2"><nlm:aff id="A10">University of California at San Francisco, San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California at San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Himes, Ryan" sort="Himes, Ryan" uniqKey="Himes R" first="Ryan" last="Himes">Ryan Himes</name><affiliation wicri:level="2"><nlm:aff id="A6">Baylor College of Medicine, Houston, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor College of Medicine, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Kumar, Soma" sort="Kumar, Soma" uniqKey="Kumar S" first="Soma" last="Kumar">Soma Kumar</name><affiliation wicri:level="2"><nlm:aff id="A8">Nationwide Children’s Hospital, Columbus, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Nationwide Children’s Hospital, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Morinville, Veronique D" sort="Morinville, Veronique D" uniqKey="Morinville V" first="Veronique D." last="Morinville">Veronique D. Morinville</name><affiliation wicri:level="4"><nlm:aff id="A11">Montreal Children’s Hospital, McGill University, Montreal, QC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Children’s Hospital, McGill University, Montreal, QC</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Lowe, Mark E" sort="Lowe, Mark E" uniqKey="Lowe M" first="Mark E." last="Lowe">Mark E. Lowe</name><affiliation wicri:level="2"><nlm:aff id="A2">Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children’s Hospital of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Nuehring, Neil E" sort="Nuehring, Neil E" uniqKey="Nuehring N" first="Neil E." last="Nuehring">Neil E. Nuehring</name><affiliation wicri:level="2"><nlm:aff id="A3">University of Iowa Carver College of Medicine, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Iowa Carver College of Medicine, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Ooi, Chee Y" sort="Ooi, Chee Y" uniqKey="Ooi C" first="Chee Y." last="Ooi">Chee Y. Ooi</name><affiliation wicri:level="1"><nlm:aff id="A12">Discipline of Paediatrics, School of Women’s and Children’s Health, Medicine, University of New South Wales and Sydney Children’s Hospital Randwick Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Discipline of Paediatrics, School of Women’s and Children’s Health, Medicine, University of New South Wales and Sydney Children’s Hospital Randwick Sydney</wicri:regionArea><wicri:noRegion>University of New South Wales and Sydney Children’s Hospital Randwick Sydney</wicri:noRegion></affiliation></author><author><name sortKey="Pohl, John F" sort="Pohl, John F" uniqKey="Pohl J" first="John F." last="Pohl">John F. Pohl</name><affiliation wicri:level="2"><nlm:aff id="A13">University of Utah, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Troendle, David" sort="Troendle, David" uniqKey="Troendle D" first="David" last="Troendle">David Troendle</name><affiliation wicri:level="2"><nlm:aff id="A4">University of Texas Southwestern Medical School, Dallas, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas Southwestern Medical School, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Werlin, Steven L" sort="Werlin, Steven L" uniqKey="Werlin S" first="Steven L." last="Werlin">Steven L. Werlin</name><affiliation wicri:level="2"><nlm:aff id="A14">Medical College of Wisconsin, Milwaukee, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical College of Wisconsin, Milwaukee, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Wilschanski, Michael" sort="Wilschanski, Michael" uniqKey="Wilschanski M" first="Michael" last="Wilschanski">Michael Wilschanski</name><affiliation wicri:level="1"><nlm:aff id="A15">Hadassah Hebrew University Hospital, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Hadassah Hebrew University Hospital, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Yen, Elizabeth" sort="Yen, Elizabeth" uniqKey="Yen E" first="Elizabeth" last="Yen">Elizabeth Yen</name><affiliation wicri:level="2"><nlm:aff id="A10">University of California at San Francisco, San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California at San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Uc, Aliye" sort="Uc, Aliye" uniqKey="Uc A" first="Aliye" last="Uc">Aliye Uc</name><affiliation wicri:level="2"><nlm:aff id="A3">University of Iowa Carver College of Medicine, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Iowa Carver College of Medicine, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of pediatrics</title><idno type="ISSN">0022-3476</idno><idno type="eISSN">1097-6833</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Cholangiopancreatography, Endoscopic Retrograde</term><term>Cross-Sectional Studies</term><term>Cystic Fibrosis Transmembrane Conductance Regulator (genetics)</term><term>DNA (genetics)</term><term>DNA Mutational Analysis</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Mutation</term><term>Pancreatitis, Chronic (diagnosis)</term><term>Pancreatitis, Chronic (epidemiology)</term><term>Pancreatitis, Chronic (genetics)</term><term>Prevalence</term><term>Risk Factors</term><term>United States (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN (génétique)</term><term>Analyse de mutations d'ADN</term><term>Cholangiopancréatographie rétrograde endoscopique</term><term>Enfant</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Mutation</term><term>Mâle</term><term>Pancréatite chronique (diagnostic)</term><term>Pancréatite chronique (génétique)</term><term>Pancréatite chronique (épidémiologie)</term><term>Protéine CFTR (génétique)</term><term>Prédisposition génétique à une maladie</term><term>Prévalence</term><term>États-Unis d'Amérique (épidémiologie)</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cystic Fibrosis Transmembrane Conductance Regulator</term><term>DNA</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>United States</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Pancreatitis, Chronic</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Pancréatite chronique</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Pancreatitis, Chronic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Pancreatitis, Chronic</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN</term><term>Pancréatite chronique</term><term>Protéine CFTR</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Pancréatite chronique</term><term>États-Unis d'Amérique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Cholangiopancreatography, Endoscopic Retrograde</term><term>Cross-Sectional Studies</term><term>DNA Mutational Analysis</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Mutation</term><term>Prevalence</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de mutations d'ADN</term><term>Cholangiopancréatographie rétrograde endoscopique</term><term>Enfant</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Mutation</term><term>Mâle</term><term>Prédisposition génétique à une maladie</term><term>Prévalence</term><term>Études transversales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">To determine the clinical presentation, diagnostic variables, risk factors and disease burden in children with chronic pancreatitis.</p></sec><sec id="S2"><title>Study design</title><p id="P2">We performed a cross-sectional study of data from INSPPIRE (<bold><underline>In</underline></bold>ternational <bold><underline>S</underline></bold>tudy Group of <bold><underline>P</underline></bold>ediatric <bold><underline>P</underline></bold>ancreatitis: <bold><underline>I</underline></bold>n search for a cu<bold><underline>RE</underline></bold>), a registry of children with acute recurrent pancreatitis and chronic pancreatitis. Between-group differences were compared using Wilcoxon rank-sum test.</p></sec><sec id="S3"><title>Results</title><p id="P3">Among 170 subjects in the registry, 76 (45%) had chronic pancreatitis; 57% were female, 80% were Caucasian, median age at diagnosis was 9.9 years. Pancreatitis-predisposing genetic mutations were identified in 51 (67%) and obstructive risk factors in 25 (33%). Toxic/metabolic and autoimmune factors were uncommon. Imaging demonstrated ductal abnormalities and pancreatic atrophy more commonly than calcifications. Fifty-nine (77%) reported abdominal pain within the past year; pain was reported as constant and receiving narcotics in 28%. Children with chronic pancreatitis reported a median of 3 emergency room visits and 2 hospitalizations in the last year. Forty-seven subjects (70%) missed one day of school in the past month due to chronic pancreatitis; 26 (34%) missed 3 or more days. Children reporting constant pain were more likely to miss school (p=0.002), visit emergency room (p=0.01) and experience hospitalizations (p=0.03) compared with children with episodic pain. Thirty-three children (43%) underwent therapeutic ERCP; one or more pancreatic surgeries were performed in 30 (39%).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Chronic pancreatitis occurs at a young age with distinct clinical features. Genetic and obstructive risk factors are common, and disease burden is substantial.</p></sec></div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Israël</li><li>États-Unis</li></country><region><li>Californie</li><li>Iowa</li><li>Massachusetts</li><li>Minnesota</li><li>Ohio</li><li>Pennsylvanie</li><li>Québec</li><li>Texas</li><li>Utah</li><li>Washington (État)</li><li>Wisconsin</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Schwarzenberg, Sarah Jane" sort="Schwarzenberg, Sarah Jane" uniqKey="Schwarzenberg S" first="Sarah Jane" last="Schwarzenberg">Sarah Jane Schwarzenberg</name></region><name sortKey="Ahuja, Monika" sort="Ahuja, Monika" uniqKey="Ahuja M" first="Monika" last="Ahuja">Monika Ahuja</name><name sortKey="Barth, Bradley" sort="Barth, Bradley" uniqKey="Barth B" first="Bradley" last="Barth">Bradley Barth</name><name sortKey="Bellin, Melena" sort="Bellin, Melena" uniqKey="Bellin M" first="Melena" last="Bellin">Melena Bellin</name><name sortKey="Davis, Heather" sort="Davis, Heather" uniqKey="Davis H" first="Heather" last="Davis">Heather Davis</name><name sortKey="Fishman, Douglas S" sort="Fishman, Douglas S" uniqKey="Fishman D" first="Douglas S." last="Fishman">Douglas S. Fishman</name><name sortKey="Freedman, Steven D" sort="Freedman, Steven D" uniqKey="Freedman S" first="Steven D." last="Freedman">Steven D. Freedman</name><name sortKey="Gariepy, Cheryl E" sort="Gariepy, Cheryl E" uniqKey="Gariepy C" first="Cheryl E." last="Gariepy">Cheryl E. Gariepy</name><name sortKey="Giefer, Matthew J" sort="Giefer, Matthew J" uniqKey="Giefer M" first="Matthew J." last="Giefer">Matthew J. Giefer</name><name sortKey="Heyman, Melvin B" sort="Heyman, Melvin B" uniqKey="Heyman M" first="Melvin B." last="Heyman">Melvin B. Heyman</name><name sortKey="Himes, Ryan" sort="Himes, Ryan" uniqKey="Himes R" first="Ryan" last="Himes">Ryan Himes</name><name sortKey="Husain, Sohail Z" sort="Husain, Sohail Z" uniqKey="Husain S" first="Sohail Z." last="Husain">Sohail Z. Husain</name><name sortKey="Kumar, Soma" sort="Kumar, Soma" uniqKey="Kumar S" first="Soma" last="Kumar">Soma Kumar</name><name sortKey="Lowe, Mark E" sort="Lowe, Mark E" uniqKey="Lowe M" first="Mark E." last="Lowe">Mark E. Lowe</name><name sortKey="Nuehring, Neil E" sort="Nuehring, Neil E" uniqKey="Nuehring N" first="Neil E." last="Nuehring">Neil E. Nuehring</name><name sortKey="Pohl, John F" sort="Pohl, John F" uniqKey="Pohl J" first="John F." last="Pohl">John F. Pohl</name><name sortKey="Troendle, David" sort="Troendle, David" uniqKey="Troendle D" first="David" last="Troendle">David Troendle</name><name sortKey="Uc, Aliye" sort="Uc, Aliye" uniqKey="Uc A" first="Aliye" last="Uc">Aliye Uc</name><name sortKey="Werlin, Steven L" sort="Werlin, Steven L" uniqKey="Werlin S" first="Steven L." last="Werlin">Steven L. Werlin</name><name sortKey="Yen, Elizabeth" sort="Yen, Elizabeth" uniqKey="Yen E" first="Elizabeth" last="Yen">Elizabeth Yen</name></country><country name="Canada"><noRegion><name sortKey="Durie, Peter R" sort="Durie, Peter R" uniqKey="Durie P" first="Peter R." last="Durie">Peter R. Durie</name></noRegion><name sortKey="Gonska, Tanja" sort="Gonska, Tanja" uniqKey="Gonska T" first="Tanja" last="Gonska">Tanja Gonska</name><name sortKey="Morinville, Veronique D" sort="Morinville, Veronique D" uniqKey="Morinville V" first="Veronique D." last="Morinville">Veronique D. Morinville</name></country><country name="Australie"><noRegion><name sortKey="Ooi, Chee Y" sort="Ooi, Chee Y" uniqKey="Ooi C" first="Chee Y." last="Ooi">Chee Y. Ooi</name></noRegion></country><country name="Israël"><noRegion><name sortKey="Wilschanski, Michael" sort="Wilschanski, Michael" uniqKey="Wilschanski M" first="Michael" last="Wilschanski">Michael Wilschanski</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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